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PNQ 370 useful in treating Parkinson’s disease from ADVINUS
2016 PNQ 370 Advinus Therapeutics Ltd Adenosine A2a receptor antagonist for treating disease or disorder susceptible to improvement by antagonism of A2A receptor. Advinus Therapeutics is...
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PNQ 201 from Advinus for for potential treatment of IBD.
PNQ 201 STRUCTURE COMING…… Adenosine A2b receptor antagonist Advinus Therapeutics Ltd KEEP WATCHING THIS POST…………… PNQ-201 is a proprietary orally active A2B Adenosine receptor (A2BAdoR) antagonist,...
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PNQ 103 from Advinus for the potential treatment of COPD & sickle cell...
PNQ 103 STRUCTURE COMING………… for the potential treatment of COPD & sickle cell disease (SCD) Adenosine A2b receptor antagonist Advinus Therapeutics Ltd KEEP WATCHING THIS POST………. PNQ-103 is a...
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Fluorofenidone
Fluorofenidone 1- (3-fluorophenyl) -5-methyl – 2 (1H) pyridone 2(1H)-Pyridinone, 1-(3-fluorophenyl)-5-methyl- 1- (3_ fluorophenyl) -5_ methylpyridine _2 (IH) – one C12 H10 F N O, 203.2123...
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TECOVIRIMAT
Tecovirimat 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop(f)isoindol-2(1H)-yl)-benzamide N- [(3aR,4R,4aR,5aS,6S, 6aS)- 3,3a,4,4a,5,5a,6,6a- octahydro-1,3-dioxo-...
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Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
Recently, application of the flow technologies for the preparation of fine chemicals, such as natural products or Active Pharmaceutical Ingredients (APIs), has become very popular, especially in...
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Merck’s Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP)
Indoline 7 as in ACS MEDCHEM LETTERS, DOI: 10.1021/acsmedchemlett.5b00404 and eg 10 as in WO2015054088 (2R)- 1,1,1 -trifluoro-3-(3-(3-(trifluoromethoxy)benzyl)-3-(3-...
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FK-3311
FK-3311 FK 3311; 116686-15-8; FK-3311; N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide; COX-2 Inhibitor V, FK3311; FK3311; A prostaglandin receptor antagonist potentially for the...
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Preclinical characterization of substituted...
MW 422.79, MF C18 H14 Cl F3 N6 O cas 1627748-32-6 1,2,4-Triazolo[4,3-a]pyrazin-8(5H)-one,...
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FDA gives Advice on the Use of Control Charts
see………………..http://www.gmp-compliance.org/enews_05135_FDA-gives-Advice-on-the-Use-of-Control-Charts_15093,15290,15250,15405,Z-VM_n.html In our News entitled “Statistics and Process Validation: current...
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Statistics and Process Validation: current Findings of the FDA
The “new” FDA’s process validation guideline has been effective since January 2011. One considerable change was made to the original validation guideline from 1987 to put a significantly greater...
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What are “complex manufacturing processes”? A recent reply from the EMA
The Variations Regulation (EC) no. 1234/2008 of the European Commission defines the procedure for variations of existing marketing authorisations. The “detailed guidelines for the various categories...
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Dofequidar fumarate
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AZD 2716
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BMS 955829
(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one (4R,5R)-5(2,5-Difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one (4R,5R)-5-(2,5-difluorophenyl)-...
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Shanghai Hengrui’s potent inhibitors of Human Uric Acid Transporter 1 (hURAT1)
MF C 1 4 H 1 2 BrNO 2 S MW 338.21958 g / mol 1- (6-bromoquinolin-4-yl) sulfanylcyclobutane-1-carboxylic acid CAS…….1638327-48-6 Cyclobutanecarboxylic acid, 1-[(6-bromo-4-quinolinyl)thio]-...
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New Patent from Zydus Cadila, Canagliflozin, US 20160002275
US-20160002275 CADILA HEALTHCARE LIMITED [IN] DESAI, Sanjay Jagdish [IN] PARIHAR, Jayprakash Ajitsingh [IN] PATEL, Jagdish Maganlal [IN] SURYAWANSHI, Uday Suresh [IN] BHALALA, Jaisukh Bhupatbhai [IN]...
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NEW PATENT, TICAGRELOR, DR. REDDY’S LABORATORIES LIMITED, WO 2016001851
WO 2016001851 DR. REDDY’S LABORATORIES LIMITED [IN/IN]; 8-2-337, Road No. 3, Banjara hills, Hyderabad, Telangana Hyderabad 500034 (IN) DAHANUKAR, Vilas; (IN). ELATI, Ravi Ram Chandrasekhar; (IN)....
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NEW PATENT, WO2016001844, SUN PHARMACEUTICALS, AFATINIB DIMALEATE
WO2016001844, AMORPHOUS FORM OF AFATINIB DIMALEATE SUN PHARMACEUTICAL INDUSTRIES LIMITED VERMA, Shyam Sunder; (IN). SINGH, Shravan Kumar; (IN). SINGH, Kaptan; (IN). PRASAD, Mohan; (IN) Afatinib...
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Continuous ruthenium-catalyzed methoxycarbonylation with supercritical carbon...
Catal. Sci. Technol., 2016, Advance Article DOI: 10.1039/C5CY01883H, Paper Stefan Christiaan Stouten, Timothy Noel, Qi Wang, Matthias Beller, Volker Hessel The methoxycarbonylation of cyclohexene...
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