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Lifitegrast, SAR 1118….effective inhibitor of LFA-1 interactions with ICAM-1
Lifitegrast, SAR 1118 SAR-1118-023 CAS 1025967-78-5 L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-...
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FDA approves Keytruda for advanced melanoma, First PD-1 blocking drug to...
September 4, 2014 FDA Release The U.S. Food and Drug Administration today granted accelerated approval to Keytruda (pembrolizumab) for treatment of patients with advanced or unresectable melanoma who...
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Acebutolol……..For the management of hypertension and ventricular premature...
Acebutolol N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide 3′-acetyl-4′-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide (±)-acebutolol Acetobutolol; Sectral; Prent; Neptal;...
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21′α-Cyanoanhydrovinblastine
Some derivatives ) are known as being intermediates in the preparation of anti-tumor medicaments such as vinblastine, vincristine and vinorelbine. R=CH3, vinblastine R=CHO, vincristine n=2,...
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AMRI Introduces Protein Expression & Purification Solutions
A MESSAGE FROM MICHAEL A. LUTHER, SENIOR VICE PRESIDENT DISCOVERY AND DEVELOPMENT Dear Anthony,As a company with a deep history of discovery innovation, Albany...
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EU Commission publishes long-awaited EU GMP Guide Chapters 3 and 5
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: The EU Commission has published the long-awaited, revised chapters 3 and 5 of the EU GMP Guide. The change focuses on the prevention of...
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Questions and Answers on the Topic “Pharmaceutical Water”
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: In the following News, you will find questions on pharmaceutical water preparation and distribution frequently asked during our courses,...
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MHRA’s Guidance for Software as a Medical Device (including Apps)
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: The British MHRA (Medicines and Healthcare Products Regulatory Agency) has published a guidance for developers of “software as a medical...
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RAVUCONAZOLE
Ravuconazole BMS-207147, ER-30346 BMS 207147 ER 30346 Ravuconazole UNII-95YH599JWV CAS Registry Number: 182760-06-1 CAS Name:...
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Fosravuconazole in phase 1 for the treatment of fungal infections.
Fosravuconazole Phosphoric acid 2(R)-[4-(4-cyanophenyl)thiazol-2-yl]-1(R)-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyoxymethyl monoester...
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Tioconazole UK-20349 an antifungal agent
Tioconazole;UK-20349;Trosyd;Trosyl;Vagistat-1 l-[2-(2-chloro-3-thienyl)methoxy]-2-(2,4- dichlorophenyl)ethyl]-lH-imidazole,...
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Tecadenoson…………Atrial Fibrillation
Tecadenoson CAS : 204512-90-3 N-[(3R)-Tetrahydro-3-furanyl]adenosine (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol N-(3-Tetrahydrofuranyl)-6-aminopurine...
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Infinity and AbbVie partner to develop and commercialise Duvelisib for...
Duvelisib Infinity and AbbVie partner to develop and commercialise duvelisib for cancer INK 1197; IPI 145; 8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone...
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Albaconazole
Albaconazole Also known as: UNII-YDW24Y8IAB; UR-9825; 187949-02-6; UR 9825, W-0027 Molecular Formula: C20H16ClF2N5O2 Molecular Weight: 431.823146...
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Teva’s Asthma Drug ‘Significantly’ Improves Lung Function In Phase 3 Trials
// Reslizumab CAS 241473-69-8 PETAH TIKVA (dpa-AFX) – Teva Pharmaceutical Industries Ltd. (TEVA) Monday said asthma patients with elevated eosinophils showed significant improvement in lung function...
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New Route to Paricalcitol
Synthesis offers potential routes to analogues of vitamin-D-based drug Paricalcitol, an A-ring-modified 19-nor analogue of 1α,25-dihydroxyvitamin D2, is currently used for the treatment and prevention...
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IMATINIB
Imatinib CAS No:- [152459-95-5] IUPAC Name:- 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide M. P.:- 211-213 °C MW: 493.604...
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Commentary Regarding new USP Chapters and for Particulate Matter Guidance
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: Commentary Regarding new USP Chapters and for Particulate Matter Guidance There are new chapters in the USP regarding testing of...
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Still a GMP problem? Or already a criminal act? Do we need more stringent...
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: Still a GMP problem? Or already a criminal act? Do we need more stringent measures and enforcement in certain situations? Sometimes EU and...
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GMP Question & Answer Guide
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: GMP Question & Answer Guide The requirements defined in the GMP Guidelines often leave room for interpretation. However, regulators...
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