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Ramatroban

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Ramatroban
Ramatroban
CAS  116649-85-5
(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
(+)-(3R)-3-(p-fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid; (+)-3-(4-fluorophenylsulfonamido)-9-(2-carboxyethyl)-1,2,3,4-tetrahydrocarbazole
3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
Manufacturers’ Codes: Bay u 3405
  1. 3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid
  2. BAY u 3405
  3. BAY u 3406
  4. BAY u-3405
  5. BAY u3405
  6. ramatroban
Trademarks: Baynas (Bayer)
MF: C21H21FN2O4S
MW: 416.47
Percent Composition: C 60.56%, H 5.08%, F 4.56%, N 6.73%, O 15.37%, S 7.70%
Properties: Crystals from ether, mp 134-135°. [a]D +70.1° (c = 1.0 in methanol).
Melting point: mp 134-135°
Optical Rotation: [a]D +70.1° (c = 1.0 in methanol)
Therap-Cat: Antiasthmatic; antiallergic.
Antiasthmatic (Nonbronchodilator); Thromboxane A2-Receptor Antagonist.

Ramatroban (INN) is a thromboxane receptor antagonist.[1]

It is also a CRTH2 antagonist.[2]

It is indicated for the treatment of coronary artery disease.[3] It has also been used for the treatment of asthma.[4]

It was developed by the German pharmaceutical company Bayer AG and is co-marketed in Japan by Bayer and Nippon Shinyaku Co. Ltd. under the tradename Baynas.

Ramatroban.png

 

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The synthesis of Bay u 3405 was carried out as follows: Reductive amination of 3-oxo-1,2,3,4-tetrahydrocarbazole (I) with S-phenethylamine (II) afforded a mixture of diastereomeric amines, of which the desired isomer (III) crystallized in high diastereomeric purity as the hydrogensulfate. Cleavage of the phenethyl group by transfer hydrogenolysis with amminium formate and palladium on charcoal yielded the enantiomerically pure (3R)-3-amino-1,2,3,4-tetrahydrocarbazole (IV). Sulfonylation of (IV) with 4-fluorobenzenesulfonyl chloride (V) to the sulfonamide (VI) followed by addition of acrylonitrile and subsequent hydrolysis gave Bay u 3405.

 

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The synthesis of [14C]-labeled Bay-u-3405 by two closely related ways has been described: 1) [14C]-Labeled aniline (I) is diazotized and reduced with sodium sulfite, yielding the labeled hydrazine (II), which is condensed with the monoketal of cyclohexane-1,4-dione (III) under Fisher’s indole synthesis (ZnCl2) to afford the tetrahydrocarbazole (IV). The hydrolysis of (IV) with HCl in THF/water yields 1,2,3,4-tetrahydrocarbazol-3-one (V), which is submitted to a reductive condensation with (S)-1-phenylethylamine (VI) by means of tetrabutylammonium borohydride, yielding preferentially the secondary amine (VII), which, after purification, is dealkylated with ammonium formate and Pd/C to afford 1,2,3,4-tetrahydrocarbazole-3(R)-amine (VIII). The acylation of (VIII) with 4-fluorophenylsulfonyl chloride (IX) gives the corresponding sulfonamide (X), which is condensed with acrylonitrile by means of NaH, yielding 3-[3(R)-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydrocarbazol-9-yl]pro pionitrile (XI). Finally, this compound is hydrolyzed in the usual way. 2) The condensation of the sulfonamide (X) with methyl acrylate by means of NaH as before gives 3-[3(R)-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydrocarbazol-9-yl]propionic acid methyl ester (XII), which is finally hydrolyzed in the usual way.

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http://pubs.rsc.org/en/content/articlelanding/2012/oc/c2oc90018a#!divAbstract

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http://onlinelibrary.wiley.com/doi/10.1002/adsc.201300993/abstract

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This invention relates to 2-amino- tetrahydrocarbazole-propanoic acid and a new process for its synthesis .

2-Amino-tetrahydrocarbazole-propanoic acid is a key intermediate for the synthesis of Ramatroban, a thromboxaneA2 receptor (TP) antagonist with clinical efficacy in asthma and allergic rhinitis.

Figure imgf000002_0001

Ramatroban l-Amino-tetrahydrocarbazole-proanoic acid

US Patent 4988820 discloses the synthesis of this compound stating from compound 1, which is condensed with phenylhydrazine and ring-closed to give indole 2. Deprotection of 2 using acid provides ketone 3. Reductive amination of ketone with s-phenylethylamine in the presence of tetrabutylammonium borohydride provides compound 4, which undergoes palladium catalyzed hydrogenation to give key intermediate 5.

Figure imgf000003_0001

Ramatroban

Figure imgf000003_0002

The process, however, has disadvantages: the starting material 1 is relatively expensive, and the yield of the amination step is only 40% and needs expensive tetrabutylammonium borohydride as the reducing agent. And also the subsequent hydrogenation provides only 70% of the desired compound 5. [0006] US Patent 4988820 also describes an alternative synthesis of compound 5 starting from compound 6, which is oxidized by chromium trioxide to afford ketone 7. Condensation of compound 7 with phenylhydrazine and ring closure give indole 8. The subsequent hydrolysis using HCl provides indole 9. The intermediate 5 is obtained by resolution of racemic 9 using ( + ) -mandelic acid as the resolving agent.

Figure imgf000004_0001

9 5

However, this process has crucial disadvantages: the first step oxidation reaction needs the heavy metal reagent chromium trioxide, which is toxic and expensive, and the resolution of indole 9 using (+) -mandelic acid affords only -10 % of compound 5.

US Patent 5684158 discloses the synthesis of 2- amino-tetrahydrocarbazole-propanoic acid ethyl ester 10 by the alkylation of compound 5 in the presence of about 1 mol of alkali metal hydroxides and phase-transfer catalysts such as potassium hydroxide and benzyltriethylammonium chloride.

Figure imgf000004_0002

The problem with this reaction is that the insoluble material in the reaction mixture becomes very sticky during the reaction. The reaction mixture must be filtered in hot solvent in order to remove insoluble material during work up and the sticky material tents to block the filtration. [0010] Therefore, there is a great need for a new process for the synthesis of 2-amino-tetrahydrocarbazole- propanoic acid.

 ……………
Example 53
  • 9- (2-carboxyethyl) -4- (4-fluorphenylsulfonamidomethyl) -1,2,3,4-tetrahydrocarbazole
    Figure imgb0092
  • 0.91 g 9-(2-Cyanoethyl)-4-[N-(4-fluorphenylsulfonyl)-N-(2-cyanoethyl)aminomethyl]-1,2,3,4-tetrahydrocarbazol be hydrolyzed analogously to Example 7. One obtains 0.77 g (89% of theory) of crystalline product as the sodium salt.
  • M.p .: 160 ° CR f = 0.57 CH 2 Cl 2: CH 3 0H = 9: 1
Example 69
    • (+) – 3- (4-fluorophenylsulphonamido) -9- (2-carboxyethyl) -1,2,3,4-tetrahydrocarbazole
      Figure imgb0106
    • 5.8 g (0.0128 mol) of Example 67 are dissolved in 60 ml isopropanol, treated with 130 ml of 10% potassium hydroxide solution, after 16 hours heating under reflux, is cooled, diluted with water and extracted with ethyl acetate. The aqueous phase is concentrated in vacuo and then treated dropwise with vigorous stirring with conc.Hydrochloric acid. The case precipitated acid is filtered off, washed with water and dried thoroughly in vacuo.Obtained 4.4 g (86.6% of theory) of the product. .: Mp 85-95 ° C rotation [α] 20 = 42.55 ° (CHCl 3) D

Example 70

  • (-) – 3- (4-fluorophenylsulphonamido) -9- (2-tarboxyethyl) -1,2,3,4-tetrahydrocarbazole
    Figure imgb0107
  • The preparation of Example 70 from Example 68 is carried out analogously to the preparation of Example 69 from Example 67. m.p .: 85-95 ° C optical rotation: [α] 20 = -37.83 ° (CHCl 3) D
……………

Synthesis pathway

Synthesis of a)




Trade names

Country Trade name Manufacturer
Japan Baynas Bayer
Ukraine no no

Formulations

  • 50 mg tablet 75 mg

Reference

  • DE 3631824 (Bayer AG; appl. 19.9.1986; prior. 21.2.1986).
  • EP 728 743 (Bayer AG; appl. 14.2.1996; D-prior. 27.2.1995).
………….
Patent Submitted Granted
Phenylsulfonamid substituted pyridinealken- and aminooxyalkan-carboxylic-acid derivatives. [EP0471259] 1992-02-19 1995-05-17
Heterocyclic substituted cycloalkano(b)-indolesulfonamides. [EP0473024] 1992-03-04
Cycloalkano[b]dihydroindoles and -indolesulphonamides substituted by heterocycles. [EP0451634] 1991-10-16 1994-03-09
Respiratory Drug Condensation Aerosols and Methods of Making and Using Them [US2009258075] 2009-10-15
ANTITHROMBOTIC SUBSTITUTED CYCLOALKANO(B)DIHYDROINDOLE- AND -INDOLE-SULPHONAMIDES [US5096897] 1992-03-17
Indolesulphonamide-substituted dihydropyridines [US5272161] 1993-12-21
THERMODYNAMICALLY STABLE FORM OF (R)-3-[ [(4-FLUOROPHENYL) SULPHONYL]AMINO] -1,2,3,4- TETRAHYDRO -9H-CARBAZOLE -9-PROPANOIC ACID (RAMATROBAN) [WO9933803] 1999-07-08
DE1695703B2 * Mar 15, 1967 Nov 20, 1975 Sumitomo Chemical Co., Ltd., Osaka (Japan) Title not available
DE2125926A1 * May 25, 1971 Jan 27, 1972 Title not available
DE2226702A1 * May 25, 1972 Dec 13, 1973 Schering Ag Neue mittel zur behandlung des diabetes mellitus
FR1415322A * Title not available
GB1487989A * Title not available
US4235901 * May 14, 1979 Nov 25, 1980 American Home Products Corporation 1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

References

  1.  Sugimoto H, Shichijo M, Iino T et al. (April 2003). “An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro”. J. Pharmacol. Exp. Ther. 305 (1): 347–52.doi:10.1124/jpet.102.046748. PMID 12649388.
  2.  Royer JF, Schratl P, Carrillo JJ et al. (September 2008). “A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils”. Eur. J. Clin. Invest. 38 (9): 663–71.doi:10.1111/j.1365-2362.2008.01989.x. PMID 18837743.
  3. Fiedler VB, Seuter F, Perzborn E (December 1990). “Effects of the novel thromboxane antagonist Bay U 3405 on experimental coronary artery disease”. Stroke 21 (12 Suppl): IV149–51.PMID 2260140.
  4. Endo S, Akiyama K (November 1996). “[Thromboxane A2 receptor antagonist in asthma therapy]”. Nippon Rinsho (in Japanese) 54 (11): 3045–8. PMID 8950952.

External links

Ramatroban
Ramatroban structure.png
Systematic (IUPAC) name
3-((3R)-3-{[(4-fluorophenyl)sulfonyl]amino}-1,2,3,4-tetrahydro-9H-carbazol-9-yl)propanoic acid
Clinical data
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number 116649-85-5
ATC code None
PubChem CID 123879
IUPHAR ligand 1910
ChemSpider 110413
UNII P1ALI72U6C Yes
ChEMBL CHEMBL361812
Chemical data
Formula C21H21FN2O4S 
Mol. mass 416.46 g/mol
References:
Thromboxane A2 receptor antagonist. Prepn: H. Böshagen et al., DE 3631824; eidem, US 4965258 (1988, 1990 both to Bayer);
Proc Natl Acad Sci USA1975,72,(8):2994-8
Science1976,193,():163-5
and absolute configuration: U. Rosentreter et al., Arzneim.-Forsch. 39, 1519 (1989).
Series of articles on pharmacology: ibid. 1522-1530.
Clinical evaluation in asthma: H. Aizawa et al., Chest 109, 338 (1996).

Filed under: Uncategorized Tagged: Bayer AG, Ramatroban

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