Quantcast
Viewing all articles
Browse latest Browse all 2871

CE-224535 for the treatment of rheumatoid arthritis and osteoarthritis

Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
UNII-T8B02RAU3C.png
Image may be NSFW.
Clik here to view.

 CE-224535

2-(4-Chloro-3-(3-(1-hydroxycycloheptyl)propanoyl)phenyl)-4-((2R)-2-hydroxy-3-methoxy-propyl)-1,2,4-triazine-3,5-dione

Benzamide, 2-chloro-5-(4,5-dihydro-4-((2R)-2-hydroxy-3-methoxypropyl)-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-n-((1-hydroxycycloheptyl)methyl)-

2-chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide

Phase III

A P2X7 receptor antagonist potentially for the treatment of rheumatoid arthritis and osteoarthritis.

CE-224535

CAS No. 724424-43-5

mw 480.9, C22H29ClN4O6

DETAILS COMING…………….

US7407956

https://www.google.com.ar/patents/US7407956

compounds of the formula I may be prepared according to the following reaction schemes and discussion. Unless otherwise indicated R1 through R7 in the reaction schemes and discussion that follows are as defined above.

 

 

Patent Submitted Granted
Methods for preparing P2X7 inhibitors [US2005288288] 2005-12-29
Combination therapies utilizing benzamide inhibitors of the P2X7 receptor [US2006018904] 2006-01-26
Methods for preparing P2X7 inhibitors [US7235657] 2005-12-29 2007-06-26
Benzamide inhibitors of the P2X7 receptor [US7176202] 2006-02-23 2007-02-13
Benzamide Inhibitors of the P2X7 Receptor [US7671053] 2009-02-12 2010-03-02
Benzamide inhibitors of the P2X7 Ereceptor [US6974812] 2004-09-16 2005-12-13
Benzamide Inhibitors of The P2X7 Receptor [US7407956] 2007-12-06 2008-08-05

/////////CE-224535, CE 224535

COC[C@@H](Cn1c(=O)cnn(c1=O)c2ccc(c(c2)C(=O)NCC3(CCCCCC3)O)Cl)O


Filed under: Phase3 drugs Tagged: CE-224535, PHASE 3 Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.
Image may be NSFW.
Clik here to view.

Viewing all articles
Browse latest Browse all 2871

Trending Articles



<script src="https://jsc.adskeeper.com/r/s/rssing.com.1596347.js" async> </script>