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CE-224535
2-(4-Chloro-3-(3-(1-hydroxycycloheptyl)propanoyl)phenyl)-4-((2R)-2-hydroxy-3-methoxy-propyl)-1,2,4-triazine-3,5-dione
Benzamide, 2-chloro-5-(4,5-dihydro-4-((2R)-2-hydroxy-3-methoxypropyl)-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-n-((1-hydroxycycloheptyl)methyl)-
2-chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide
Phase III
A P2X7 receptor antagonist potentially for the treatment of rheumatoid arthritis and osteoarthritis.
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CE-224535
CAS No. 724424-43-5
mw 480.9, C22H29ClN4O6
DETAILS COMING…………….
US7407956
https://www.google.com.ar/patents/US7407956
compounds of the formula I may be prepared according to the following reaction schemes and discussion. Unless otherwise indicated R1 through R7 in the reaction schemes and discussion that follows are as defined above.
| Patent | Submitted | Granted |
|---|---|---|
| Methods for preparing P2X7 inhibitors [US2005288288] | 2005-12-29 | |
| Combination therapies utilizing benzamide inhibitors of the P2X7 receptor [US2006018904] | 2006-01-26 | |
| Methods for preparing P2X7 inhibitors [US7235657] | 2005-12-29 | 2007-06-26 |
| Benzamide inhibitors of the P2X7 receptor [US7176202] | 2006-02-23 | 2007-02-13 |
| Benzamide Inhibitors of the P2X7 Receptor [US7671053] | 2009-02-12 | 2010-03-02 |
| Benzamide inhibitors of the P2X7 Ereceptor [US6974812] | 2004-09-16 | 2005-12-13 |
| Benzamide Inhibitors of The P2X7 Receptor [US7407956] | 2007-12-06 | 2008-08-05 |
/////////CE-224535, CE 224535
COC[C@@H](Cn1c(=O)cnn(c1=O)c2ccc(c(c2)C(=O)NCC3(CCCCCC3)O)Cl)O
Filed under: Phase3 drugs Tagged: CE-224535, PHASE 3 Image may be NSFW.
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