(S)-2-amino-butanamide hydrochloride………. Key intermediate of Levetiracetam
(S)-2-amino-butanamide hydrochloride
Key intermediate of Levetiracetam
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CAS Number 7682-20-4
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Linear Formula CH3CH2CH(NH2)CONH2 · HCl
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Stage B
(S)-2-aminobutyramide hydrochloride Preparation
Into the above (S)-2-aminobutyric acid methyl ester hydrochloride is added Isopropanol is then added, followed by the introduction of ammonia gas at a pressure about 60 psi (413 kPa) until the reaction is complete. After filtering to remove formed ammonium chloride, the solvent is partially evaporated and isopropanol hydrochloride is added. The mixture is stirred while solid product forms, then the solid is separated by filtration and washed with isopropanol.
The product was characterized by the following 1H NMR data (200 MHz, DMSO-d6): 0.9-1.0(t,3H), 1.8-1.9(Q,2H), 3.7-3.8(t, 1H), 7.5-7.7(Br,NH2), 8.0-8.2(Br,NH2)
1H NMR PREDICT
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13C NMR PREDICT
P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent.
P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent.
P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent.
COCK WILL TEACH YOU NMR
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amcrasto@gmail.comFiled under: spectroscopy Tagged: (S)-2-amino-butanamide hydrochloride, intermediate, LEVETIRACETAM
